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Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human close-phase failing hearts.
More rapidly drug approval periods as well as other PDUFA-relevant changes have triggered pharmaceutical companies targeting far more medications for 1st launch in The usa thus escalating affected individual use of new medicines. More quickly drug overview from 1990 to 2001 were being located to enhance the probability of a drug getting released first in The us by fourteen%.
Improvements in eicosapentaenoic acid and docosahexaenoic acid and threat of cardiovascular situations and atrial fibrillation: a secondary Evaluation with the omemi demo.
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When Congress was debating the laws that applied PDUFA II Rep. Billy Tauzin, who later grew to become head of PhRMA and a type of foremost the call for an extra streamlined critique approach, advised a Tale of how a family friend needed to travel to Mexico to acquire medications that aided him triumph over prostate most cancers.
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As a result, the scientific importance of PUFAs for cardiovascular disease is the subject of study and discussion, but all questions haven't been answered to this point.
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The ability of docosahexaenoic acid, eicosapentaenoic acid and alpha-linolenic acid to dam cardiac sodium currents was uncovered to correlate with their skill to enhance membrane fluidity of isolated Grownup rat ventricular myocytes (123).
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